WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. WebTMEPAI was known to be induced by TGF-β/Smad signaling and have tumorigenic functions that converting TGF-β from tumor suppressor to tumor promoter and inducing epithelial–mesenchymal transition (EMT). ... (IC50) of several anti-cancers: doxorubicin, cisplatin, paclitaxel, and bicalutamide in the presence of TGF-β treatment.Results: KO ...
Cisplatin chemotherapy and renal function - PubMed
WebOct 3, 2024 · Unfortunately, some chemotherapies can also cause strokes, such as methotrexate, cisplatin, imatinib and more. Some agents, such as bevacizumab and sunitinib, intentionally target blood vessels since tumors often create new vessels to send nutrients to the abnormal growth. Unfortunately, side effects can include hemorrhage or … WebCisplatin, a chemotherapy medication used to treat BC, not only rapidly kills proliferating cancer cells but also affects the tumor immune microenvironment. However, the mechanism underlying this phenomenon is largely unknown. pist idiots juliette
Cisplatin (chemotherapy drug) - treatment and side effects
WebSep 15, 2024 · Cisplatin forms irreversible covalent links with DNA, causing cross linking of DNA chains as well as breaks in the DNA chain and missense mutations. The DNA injury … WebNov 10, 2024 · Many widely-used chemotherapies, like cisplatin, kill tumors by damaging their DNA and inducing programmed cell death. But cells are resilient, and many can continue to function with the help of repair enzymes that simply bypass the damage and continue to replicate the DNA. WebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. … atlassian spike