Dichloromethane mutagenicity

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WebProduct name : Dichloromethane Product Number : 270997 Brand : Sigma-Aldrich Supplier : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +1 800-325-5832 ... Germ cell mutagenicity Genotoxicity in vivo - rat - Oral DNA damage Carcinogenicity Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS … WebSix chicken-essence concentrates (CEC) or their dichloromethane extracts (DECE) showed inhibition of the mutagenicity of indirect environmental mutagens such as 2-amino-3-methylimidazo[4,5- f]quinoline (IQ), 3-amino-l-methyl-5-H-pyrido[4,3-b] indole (Trp-P-2), and benzo[a]pyrene (B[a)P), but contrarily had no effect on direct environmental ...

Enzyme-mediated dichloromethane toxicity and …

WebNov 28, 2016 · 1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees … WebJan 1, 1978 · The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was … ipoh hot spring

Dichloromethane - an overview ScienceDirect Topics

WebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes … WebDichloromethane is no longer produced in Canada (CPI, 2000). From 1977 to 1990, the quantity of dichloromethane imported and used in Canada ranged annually from 9 to 13.2 kilotonnes (Environment Canada, 1990); however, usage of pure dichloromethane, recycled dichloromethane and dichloromethane contained in formulations has … WebU.S EPA Web Server orbit wheelchair repair

Methanol 10% in Dichloromethane - Columbus Chemical …

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WebProduct name : Dichloromethane CAS-No. : 75-09-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 WebMethylene Chloride is a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of … orbit wheelchair partsWebAug 15, 1983 · Four dihalomethanes; dichloromethane, bromochloromethane, dibromomethane and diiodomethane, have been studied with respect to their reactivities … ipoh hub shopee express

"WebDichloromethane, Methylene dichloride CAS No. 75-09-2 RTECS No. PA8050000. DOT ID & Guide. 1593 160. Formula. CH₂Cl₂ ... " - Dichloromethane mutagenicity

Dichloromethane mutagenicity

Lack of in vivo mutagenicity of 1,2-dichloropropane and dichloromethane …

WebMutagenicity: DNA inhibition: Human, Fibroblast = 5000 ppm/1H (Continuous).; Morphological transformation: Rat, Embryo = 160 umol/L.; DNA damage: Oral, rat = 1275 mg/kg.; ... The neurotoxicity is thought to be due to a direct nonspecific CNS depressant action of dichloromethane and to indirect effects of carbon monoxide. … WebTheir mutagenicity was examined with Salmonella typhimurium TA98 in presence or absence of S9 mix. The total mutagenic activity of the acetone extract was 1.8-7.0-fold that of the dichloromethane extract. ... However, the amount of pyrene in the dichloromethane extract was much higher than in the acetone extract. These results indicate that the ...

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Hepatic toxicity. Hepatic effects are commonly observed forms of toxicity following inhalation (Burek et al. 1984; Nitschke et al. 1988) or oral (Serota et al. 1986a) dichloromethane exposure in rodents. Changes observed in animals following dichloromethane exposure include liver foci/areas of alteration, … See more In 2011, the Integrated Risk Information System (IRIS) of the U.S. Environmental Protection Agency (EPA) released an updated Toxicological Review of Dichloromethane (Methylene Chloride) (U.S. EPA 2011). In … See more The toxicological review was developed according to the general risk assessment guidelines (National Research Council 1983, 1994). The literature search strategy was based on the … See more In summary, the IRIS Toxicological Review of Dichloromethane (U.S. EPA 2011) developed noncancer reference dose values for oral … See more Dichloromethane metabolism occurs primarily in the liver but also in lung tissues, particularly in mice. The PBPK model structure for dichloromethane traces back to one … See more Web1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees working in printing plant in Osaka, Japan. However, few reports have demonstrated an association between these agents and cholangiocarcinoma in rod …

WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & … WebDichloromethane caused a reproducible positive response in bacterial tester strains TA98, TA100, TA1535, and G46 at all doses used with these strains, both with and …

WebJan 9, 2006 · Mutagenicity: mutagenic in salmonella typhimurium Ames assay : Gene mutation in hamster ovary cells (3,000 ppm) : DNA damage in mouse liver cells (400 u mol/L) OTHER DATA: Limited evidence of a carcinogenic effect. Component Carcinogenicity Dichloromethane (75-09-2) ACGIH: A3 - Confirmed animal carcinogen with unknown … WebSep 1, 1983 · The metabolic activation and mutagenicity of dichloromethane and chlorofluoromethane were investigated using rat liver fractions and Salmonella typhimurium strain TA100. Both dihalomethanes gave a mutagenic response without the addition of rat-liver fractions. This response has been shown to be due to bacterial metabolism of the …

WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases. The kinetic properties of bacterial …

WebThe mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast … ipoh ict contractorWebfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This ipoh houses for saleWebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - … ipoh hotels with poolWebMutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). ... Methanol (90%) and dichloromethane ... ipoh hydrotech engineering sdn bhdWebDichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a bacterial mutagen. It has been suggested that the bacterial mutagenicity of DCM is mediated by glutathione (GSH) conjugation. The involvement of endogenous and exogenous GSH in the con … orbit wheelchair naperville ilWebGerm cell mutagenicity Ames test S. typhimurium Result: negative Mutagenicity (micronucleus test) Hamster - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No … ipoh hotels with balcony ipoh ice cream