Dsg3 ko mice
Web21 nov 2012 · To better understand the role of desmosomal cadherins in cancer, we employed mice lacking the desmosomal cadherin Dsg3, which are viable yet in which … WebAccordingly, Dsg3 knock out (ko) mice show a mild PV like phenotype with mainly oral lesions and PV typical loss of cell-cell adhesion in suprabasal layers (12, 13). In contrast, ...
Dsg3 ko mice
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WebUsing knockout mice lacking desmoglein 3 (Dsg3), the target antigen of pemphigus vulgaris (PV), we have generated an active disease model for this autoantibody-mediated … WebIrradiated mice (750 rads) reconstituted with BM from wild‐type or CD4 – or CD8α – KO mice all produced stable chimerism and tolerance. However, BM from CD4 – and CD8α – double KO or CD3‐transgenic BM lacking both T cells and NK cells, caused rejection of corresponding wild‐type grafts, despite stable chimerism.
WebThese results demonstrate that anti-Dsg3 autoantibodies interfere with the cell-cell adhesion of keratinocytes in PV model mice. In conclusion, our model mice closely represent the … WebBio-Rad dsg3 knockout ko mice Dsg3 Knockout Ko Mice, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS …
Web1 lug 2016 · Cyclic alopecia has also been observed in other transgenic mice including Ctsl-KO mice, Dsg3-KO mice, in mice with deletion of the calcineurin gene specifically in keratinocytes, and in hematopoietic and endothelial cell-specific peroxisome proliferator-activated receptor-γ KO mice ( Koch et al., 1998, Mammucari et al., 2005, Roth et al., … WebIn the Dsg3- and Ctsl-KO mice and in the mice with keratinocyte-specific calcineurin deletion, at least two complete cycles of hair loss and regrowth were noted. In our study …
WebDsg3-specific naive lymphocytes in Dsg3(-/-) mice can be primed and activated by the endogenous Dsg3 in recipient mice to produce pathogenic anti-Dsg3 IgG without active …
Web7 dic 2024 · We used desmoglein 3 (Dsg3), a pemphigus antigen expressed in keratinocytes, to analyze peripheral tolerance under physiological antigen-expression … harjun kiekko logoWeb20 ago 2024 · DSG3 –/– DSG1 tg/tg (DSG3-KO) mice were immunized with rhDSG3, followed by splenocyte transfer into syngeneic RAG2 –/– mice. Twenty days after … pudhu vellai mazhai lyrics tamilWebKoch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR, Targeted disruption of the pemphigus vulgaris antigen … pudotuspainomittausWebWe generated a PV model via the adoptive transfer of B6-Dsg1 (tg/tg)Dsg3 (-/-) splenocytes to B6-Rag2 (-/-) mice. Results: Dsg1 (tg/tg) and Dsg1 (tg/wt) mice expressed ectopic … harjun kiekkoWebhDsg3 mice, but not WT mice, induces suprabasilar acantholysis in mucosal tissues, thus confirming the pathogenicity of mPV anti-hDsg3 IgG in vivo. Human anti-hDsg3 … pudhu vellai mazhai singersWeb1 mar 2000 · Using knockout mice lacking desmoglein 3 (Dsg3), the target antigen of pemphigus vulgaris (PV), we have generated an active disease model for this … harjun lounas kokkolaWeb21 set 2005 · Removal of anti-DSG3 autoantibodies by immunoadsorption eliminated the ability of PNP sera to induce cutaneous blisters in neonatal mice; anti-DSG3 … pudina tikka masala