WebChain procedures/graphical procedures in group-sequential and general adaptive trials (Maurer and Bretz, 2013; Sugitani, Bretz and ... Multiple testing in group sequential trials using graphical approaches. Statistics in Biopharmaceutical Research. 5, 311-320. Sugitani,T., Bretz, F., Maurer, W. (2016). A simple and flexible graphical approach ... WebDec 20, 2006 · This paper discusses multiple testing problems in which families of null hypotheses are tested in a sequential manner and each family serves as a gatekeeper for the subsequent families. Gatekeeping testing strategies of this type arise frequently in clinical trials with multiple objectives, e.g., multiple endpoints and/or multiple dose …
Graphical Approaches to Multiple Testing 25 Clinical …
WebJun 17, 2002 · Classical view. Classicists believe that if multiple measures are tested in a given study, the p-value should be adjusted upward to reduce the chance of incorrectly declaring a statistical significance [4–7].This view is based on the theory that if you test long enough, you will inevitably find something statistically significant – false-positives due to … WebIn addition, graphical approaches have been proposed that facilitate the visualization and communication of Bonferroni-based closed test procedures for common multiple test … greensboro p\u0026dc phone number
Do multiple outcome measures require p-value adjustment?
WebCarnegie Mellon University. Jan 2015 - May 20155 months. Pittsburgh. Introduction to Probability Models: Poisson processes, Markov chains, … WebA graphical multiple testing procedure with "no-dead-end" provides an opportunity to fully recycle α across hypothesis families. Two hypothetical clinical trial examples are used to … WebImplements the graphical test procedure described in Bretz et al. (2009). Note that the gMCP function in the gMCP package performs the same task. ... Bretz, F., Maurer, W., Brannath, W. and Posch, M. (2009) A graphical approach to sequentially rejective multiple test procedures. Statistics in Medicine, 28, 586--604. fmcsa drug and alcohol consortium list